ÖZGEÇMøù VE ESERLER LøSTESø ÖZGEÇMøù AdÕ-SoyadÕ: Tijen Alkan-Bozkaya Do÷um yeri ve Tarihi: østanbul, 20.05.1969 Ö÷renim Durumu : Derece Bölüm/Program Üniversite YÕl Lisans-Y.Lisans østanbul TÕp Fakültesi østanbul Üniversitesi 1992 TÕpta UzmanlÕk Kalp ve Damar Cerrahisi ø.Ü. Kardioloji Enstitüsü 1993-99 Yrd.Doc. Kalp ve Damar Cerrahisi østanbul Bilim Üniversitesi 2009 TÕpta UzmanlÕk Tezi BaúlÕ÷Õ (özeti ekte) ve DanÕúmanlarÕ: Fonksiyonel Tek Ventriküllü Hastalarda uygulanan, Fontan Sirkülasyonu ve ModifikasyonlarÕnda Atrial Natriüretik Peptid (ANP)¶in Yeri ve Önemi Tez DanÕúmanlarÕ : Prof. Dr. Tayyar SarÕo÷lu, Prof. Dr. Ayúe SarÕo÷lu Görevler: Görev UnvanÕ Intern Dr. Görev Yeri Uppsala Universitesi, Uppsala , øsveç Pediatri, Neonatal ünitesi YÕl 1991 Hükümet Tb. Sakarya ± Hendek Merkez S.O. 1992-93 Dr.Ar.Gör. østanbul Üniversitesi , Kardioloji Enstitüsü 1993-99 Op.Dr. Florence Nightingale Hastanesi 1999 Fellow-surgeon Texas Children¶s Hospital, Pediatric Cardiac Surgery 2000 Op.Dr. V.K.V. Amerikan Hastanesi 2000-2008 Op.Dr. KadÕköy Florence Nightingale Hastanesi Nisan 2008 Yard.Doç.Dr. østanbul Bilim Üniversitesi, Kalp ve Damar Cerrahisi Temmuz 2009 Projelerde yaptÕ÷Õ Görevler: UluslararasÕ Klinik AraútÕrma projelerinde proje planlayÕcÕsÕ ve uygulayÕcÕsÕ; yayÕn hakemli÷i ødari Görevler: American Artificial Organ Dergisinde yayÕn hakemli÷i Bilimsel Kuruluúlara Üyelikler : Türk Kalp ve Damar Cerrahisi Derne÷i Türk Kardiyoloji Derne÷i Türk Periferik Damar Cerrahisi Derne÷i Türk Tabibler Birli÷i Türk Pediatrik Kardiyoloji Derne÷i Türk Toraks Derne÷i EACTS (European Ass. of Cardiothoracic Surgeons) American Society of Artificial Organ Ödüller : 1- John Waldhousen ³genç araútÕrmacÕ´ ödülü ³ANP : Could it be a marker for postoperative recurrent drainage after Fontan procedures in complex congenital heart defects?´ - 2006 May, Toronto, Canada 2- AydÕn Aytaç, Prof. M.D. ³Klinik araútÕrma´ ödülü ³Benefits of pulsatile perfusion on vital organ recovery during and after pediatric open-heart surgery´ - 2007 May, Hershey, Pennsylvania ESERLER : Yard.Doç.Dr. Tijen Alkan-Bozkaya BASILI OLAN YAYINLAR Yurtdisi yayinlar : A1 1. Alkan T. Akçevin A, Ündar A, Türko÷lu H, Paker T, Aytaç A. Benefits of pulsatile perfusion on vital organ recovery during and after pediatric open heart surgery.. ASAIO J. 2007 Nov-Dec; 53(6):651-4. 2. Alkan T. , Akcevin A, Turkoglu H , Paker T, Sasmazel A, Bayer V, Ersoy C, Askin D, Aytac A. Postoperative prophylactic peritoneal dialysis in neonates and infants after complex congenital cardiac surgery.ASAIO J. 2006 Nov-Dec ;52 (6) : 693-7 3. Turkoglu H, Alkan T , Okcun B , Akcevin A, Paker T , Ersoy C, Sasmazel A, Aytac A. Symptomatic lipoma in the interventricular septum.ASAIO J. 2006 Nov-Dec; 52(6): e35-6. 4. Alkan T, Akcevin A, Turkoglu H, Paker T , Aytac A,Shprintzen (velo-cardio-facial ) syndrome: rare case. ASAIO J. 2006 Nov-Dec; 52(6):e33-4 5. Alkan T, Sarioglu A, Samanli UB, Sarioglu T, Akcevin A, Turkoglu H, Paker T, Aytac A. Atrial natriuretic peptide: Could it be a marker for postoperative recurrent effusions after Fontan circulation in complex congenital heart defekts ? ASAIO J. 2006 Sep-Oct ; 52(5) :543-8 6. Alkan T, Akcevin A , Undar A, Turkoglu H, Paker T, Aytac A, Effects of pulsatile and nonpulsatile perfusion on vital organ recovery in pediatric heart surgery:a pilot clinical study. ASAIO J. 2006 Sep-Oct ; 52 (5):530 ±5 7. Taymaz H, Erarslan S, Öner ET, Alkan T, A÷ÕrbaúlÕ M, KÕrdar B. Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population. Thrombosis Research 2007 Feb; 119, 55-62 8. Haines N, Wang S, Undar A, Alkan T, Akcevin A. Clinical Outcomes of Pulsatile and NonPulsatile Mode of Perfusion. JECT. 2009;41:26-29. A2 1. Sasmazel A, Akcevin A, Turkoglu H, Ersoy C, Alkan T, Paker T, Bayer V, Aytac A. A surgical salvage case with active endocarditis and aortic coarctation. Anadolu Kardiyol Derg. 2006 Sep;6(3): 304. No abstract avaible. 2. Sasmazel A, Alkan T, Ersoy C, Paker T, Akcevin A, Bayer V, Turkoglu H, Aytac A. (Our surgical experiences with aortopulmonary window) Anadolu Kardiyol Derg. 2006 Mar;6(1):77-8.Turkish.No abstract avaible. Yurtici Yayinlar: B 1. Turkoglu H, Alkan T. Buyuk damarlarin konjenital duzeltilmis transpozisyonu cerrahi tedavi secenekleri. Turkiye Klinikleri Konjenital Kalp Hastaliklari Ozel Sayisi. 2008 ( Basimda). 2. Sasmazel A, Alkan T, Paker T, Ersoy C, Akcevin A, Bayer V, Turkoglu H, Aytac A. St. Jude Silzone mekanik kalp kapaklarinda paravalvuler kacak ve emboli riskinin degerlendirilmesi. Turk Kardiyol Dern Ars. 2006;34(4):230-232 3. Sasmazel A, Paker T, Ersoy C, Akcevin A, Alkan T, Bayer V, Turkoglu H, Aytac A. Kombine karotis ve koroner arter cerrahisinde klinik deneyimimiz. Turkish J Vasc Surg. 2005;14(1):9-12 4. Alkan T, Turkoglu H, Akcevin A, Paker T, Ersoy C, Sasmazel A, Bayer V, Askin D, Aytac A. Kronik atriyal fibrilasyonlu hastalarda mitral kapak esnasinda elektrokoter ile cerrahi ablasyon ;Orta vadeli takip sonuclari. TGE Derg 2005;2:95-101 5. Akçevin A, Alkan-Bozkaya T. Cerrahi Ablasyonda Uygulanacak Peroperatif ve Postoperatif Medikal Tedavi Protokolleri. Medical Management During And Postoperatively In Surgical Ablation. Türkiye Klinikleri J Cardiovasc Surg- Special Topics 2008, 1:77-82. 6. Alkan-Bozkaya T., Akçevin A. Fontan Prosedürü ve ModifikasyonlarÕ: Fonksiyonel Tek ventriküllüm Hastalarda Geçmiúten Günümüze. Türkiye Klinikleri J Cardiovasc SurgSpecial Topics 2008, 1(5):43-50. BASILI OLAN BILDIRILERIM F ( a ) : UluslararasÕ kongrelerde sunulan, basÕlÕ bildiriler : 1. Alkan-Bozkaya T., Akcevin A., Ündar A*., Türko÷lu H., Paker T, Aytaç A. Pulsatile Perfusion on Vital Organ Recovery During and After Pediatric Open-Heart Surgery in Ventricular Septal DefectsThe Proceedings of the Fourth International Conference on Fourth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion May 21-24, 2008 Hilton Portland & Executive Tower Portland, Oregon,USA p 49 2. Alkan-Bozkaya T., Akcevin A., Ündar A., Türko÷lu H., Paker T., Aytaç A. Thyroid Hormones Homeostasis in Pediatric Patients During and After Cardiopulmonary Bypass: Is There a Difference Between the Pulsatile and Nonpulsatile Perfusion Modes? The Proceedings of the Fourth International Conference on Fourth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion May 21-24, 2008 Hilton Portland & Executive Tower Portland, Oregon,USAp61 3. Alkan T., Akcevin A., Ündar A*., Türko÷lu H., Paker T, Aytaç A.Benefits of Pulsatile Perfusion on Vital Organ Recovery during and after Pediatric Open-Heart Surgery The Proceedings of the Third International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion May 17±19, 2007 The Hotel Hershey Hershey, Pennsylvania, USA p 32 4. Alkan T, Akçevin A, Türko÷lu H, Paker T, Bayer V, Ersoy C, AskÕn D., Aytaç A.Postoperative Prophylactic Peritoneal Dialysis in Neonates and Infants after Complex Congenital Cardiac Surgery The Proceedings of the Third International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion May 17±19, 2007 The Hotel Hershey Hershey, Pennsylvania, USA p 39 5. Alkan T, Turkoglu H, AkcevÕn A , Oztunc F**, SaltÕk L**, Dindar A*, Paker T, Ersoy C, Bayer V, Duman U, Ozsoy F, Aytac A. Congenitally Isolated Defect on the Anterior Mitral Valve and Surgical Repair: Two Rare Cases The Proceedings of the Third International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion May 17±19, 2007 The Hotel Hershey Hershey, Pennsylvania, USA p 49 6. Alkan T, Akcevin A, Ercelen N*, Türkoglu H, Paker T, Aytac A. Congenital Heart Surgery Cases Accompanied with Genetic Syndromes The Proceedings of the Third International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion May 17±19, 2007 The Hotel Hershey Hershey, Pennsylvania, USA p 50 7. Alkan T ,Turkoglu H,Akcevin A, Paker T, Aytac A, Cardiac Surgery of Prematures and Low Birth Weight Newborns: Is It Possible to Change Fate? The Proceedings of the Third International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion May 17±19, 2007 The Hotel Hershey Hershey, Pennsylvania, USA p 87 8. Alkan T , Türko÷lu H, Akçevin A, Dindar A*, Paker T, Duman U , Öklü L**, Aytaç A. A Rare Case with Holt-Oram Syndrome and ³Swiss Cheese´ VSD: Surgical Treatment andFollow-up The Proceedings of the Third International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion May 17±19, 2007 The Hotel Hershey Hershey, Pennsylvania, USA p 91 9. Alkan T, Turko÷lu H, Dindar A*, Akcevin A, Paker T, Ersoy C, Bayer V, Aytac A. Surgical Correction of Iatrogenic Severe Aortic Insufficiency and LAD Dissection in a Case with Congenital Coronary Artery Fistula during Coil Embolization The Proceedings of the Third International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion May 17±19, 2007 The Hotel Hershey Hershey, Pennsylvania, USA p 92 10. Alkan T., Akçevin A.,Türko÷lu H., Paker T., Aytaç A.Shprintzen (Velo-cardio-facial) Syndrome: A rare case (poster presentation)The Second International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, May 18-20, 2006 in Toronto, Ontario, Canada. 11. Turko÷lu H., Alkan T.,Ökçün B., Akçevin A., Paker T., Ersoy C., ùaúmazel A., Aytaç A. Case report : Symptomatic Lipoma in the interventricular septum. (poster presentation) The Second International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, May 18-20, 2006 in Toronto, Ontario, Canada. 12. Alkan T., Ersoy C., Akçevin A., Türko÷lu H., Paker T., Aytaç A. Commerrel Diverticulum: Case Report and Surgical Approach to Vascular Rings. (poster presentation). The Second International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, May 18-20, 2006 in Toronto, Ontario, Canada. 13. Alkan T., SarÕo÷lu A., SamanlÕ Ü.B., SarÕo÷lu T., Akçevin A., Türko÷lu H., Paker T., Aytaç A. Atrial Natriuretic Peptide: Could it be a marker for postoperative recurrent effusions after Fontan circulation in complex congenital heart defects? The Second International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, May 18-20, 2006 in Toronto, Ontario, Canada. (oral presentation) 14. Alkan T., Akcevin A., Ündar A*., Türko÷lu H., Paker T., Aytaç A.Effects of Pulsatile and Nonpulsatile perfusion on vital organ recovery in Pediatric Heart Surgery : A Pilot Clinical Study (oral presentation). The Second International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, May 18-20, 2006 in Toronto, Ontario, Canada. 15. Alkan T, Akçevin A, Türko÷lu H, Paker T, ùaúmazel A, Bayer V, Ersoy C, AskÕn D., Aytaç A. Postoperative Prophylactic Peritoneal Dialysis in Neonates and Infants after Complex Congenital Cardiac Surgery. (poster presentation). The Second International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, May 18-20, 2006 in Toronto, Ontario, Canada. 16. Türkoglu H, Alkan T, Duman U, Paker T, SamanlÕ UB, Akçevin A, Aytaç A. Therapeutic value of somatotropin in treatment of postoperaive recurrent serious/chylous drainage in patients with Fontan circulation.(poster presentation). The Second Clinical Vascular Biology Congress, April 26-30, 2006. (European Journal of Clinical Investigation'da abstractÕ yayÕnlanmÕútÕr : Vol 36 No 4 : 211-292, Apr 2006) 17. Türko÷lu H, Akçevin A, Paker T, SarÕo÷lu T, Olga R, Ersoy C, Bayer MV, AúkÕn D, Kaya S, Alkan T, Aytaç A: Surgical Approach To Intracardiac Myxomas. 28 Years¶ Experiences and Results. 51st International Congress of the European Society for Cardiovascular Surgery. June 29- July 1, 2002 . C13.2 Helsinki, Finland. 18. Alkan T, Uzunhasan I, Türkoglu H, Akçevin A, ùaúmazel A, Paker T, Aytaç A. Comparison of Surgical approach for Ischemic and Non-Ischemic Mitral Regurgitation : Repair versus Replacement. (e-poster presentation). Heart Surgery Forum, Vol 9, Supplement I, P. 80, 2006. 2nd Annual Congress on Update in Cardiology and Cardiovascular Surgery, September 20-24, 2006. 19. Alkan T, Türkoglu H, Akçevin A, Paker T, Aytaç A. Surgical Correction with single approach to the combination of Aorticopulmonary window and Interrupted Aortic Arch in Neonatal period and results.(e-poster presentation). Heart Surgery Forum, Vol 9, Supplement I, P. 74,2006. 2nd Annual Congress on Update in Cardiology and Cardiovascular Surgery, September 20-24, 2006. 20. Akcevin A., Alkan-Bozkaya T., Ündar A. Pulsatile vs. Non-Pulsatile Perfusion in Neonates and Infants. Fifth International Conference on Pediatric Mechanical Circulatory Support and Pediatric Cardiopulmonary Perfusion; Conference Proceedings p 67 May 27-30 2009 Hilton Anatole Dallas Texas USA 21. Ündar A, Pauliks L, Clark JB, Zahn J, Kunselman AR, Sun Q, Pekkan K, Saliba K, Carney E, Rosenberg G, Thomas N, Freeman W, Vrana K, El-Banayosy A, Ural SH, Wilson R, Umstead TM, Floros J, Phelps DS, Weiss W, Yang AS, Kimatian S, Cyran SE, Chinchilli VM, Alkan-Bozkaya T, Akcevin A, Sun K, Wang S, Cun L, Myers JL. PENN STATE HERSHEY-INTERNATIONAL CENTER FOR PEDIATRIC CARDIOVASCULAR RESEARCH.Fifth International Conference on Pediatric Mechanical Circulatory Support and Pediatric Cardiopulmonary Perfusion; Conference Proceedings p 77-78 May 27-30 2009 Hilton Anatole Dallas Texas USA 22.Alkan-Bozkaya T., Akcevin A., Türko÷lu H, Paker T, Aytaç A. Coronary Arterio-Venous Fistual: surgical Indication in Childhood, Treatment and Results. (e-poster presentation). Fifth International Conference on Pediatric Mechanical Circulatory Support and Pediatric Cardiopulmonary Perfusion; Conference Proceedings p 103 May 27-30 2009 Hilton Anatole Dallas Texas USA F ( b ) : Ulusal kongrelerde sunulan, basÕlÕ bildiriler : 1. Alkan T, Paker T, Akcevin A, Turkoglu H , Bayer MV, Ersoy C, Sasmazel A, Kaya S, Aytac A: Koroner Bypass cerrahisinde kullanilan radial arter grefti cikarildiktan sonra el fonksiyonlarinin ve sonuclarinin degerlendirilmesi.XII. Ulusal Turk kalp Damar Cerr. Dern. Kong. Antalya, 23-27 Ekim , 2002. 2. Alkan T, Paker T, Turkoglu H , Akcevin A, Ersoy C, Bayer MV, Sezer D, Askin D, Aytac A: Ring Annuloplastiler : Ne zaman ve neden yapalim? XII . Ulusal Turk Kalp Damar Cerr. Dern. Kong. Antalya, 23-27 Ekim, 2002. 3. Turkoglu H , Akcevin A ,Paker T , Sarioglu A, Ikizler C , Olga R, Ersoy C, Bayer MV , Alkan T, Kaya S, Aytac A: Intrakardiyak yerlesimli miksomalara cerrahi yaklasim ,28 yillik tecrubemiz ve sonuclar.XII. Ulusal Turk Kalp Damar Cerr. Kong. Antalya , 23-27 Ekim,2002. 4. T.Alkan, A.Hasanefendio÷lu Bayrak, B.Çolako÷lu, A.Akçevin, ,H.Türko÷lu, T. Paker, A.Aytaç. Karotis endartektomi sonrasÕ operasyon tarafÕnda ve karúÕ tarafta aterosklerotik plak geliúim ve progresyonunun Dupleks Dopler ile taranmasÕ ve kÕsa-orta vade sonuçlarÕmÕz. (sözlü sunum). Türk Kardiyol Dern Arú Vol 34, Suppl 1 , Oct, 2006, SB-138, s.68. XXII. Ulusal Kardioloji Kongresi, 24-28 KasÕm, 2006, Antalya 5. H. Türko÷lu, T. Alkan, A. Dindar, A.Akçevin, T.Paker, Ü.Duman, L. Öklü, A.Aytaç. HoltOram Sendromu ve Multipl VSD¶li nadir bir olgu : TanÕ, Cerrahi tedavi ve øzlem. (poster sunumu). Türk Kardiyol Dern Arú Vol 34, Suppl 1 , Oct, 2006, P-194, s.102. XXII. Ulusal Kardioloji Kongresi, 24-28 KasÕm, 2006, Antalya 6. T. Alkan, A. Akçevin, H. Türko÷lu, T. Paker, U. Zor, A. Aytaç. Kalbin primer tümörlerine cerrahi yaklaúÕm ve sonuçlarÕmÕz : 23 olgu. (sözlü sunum). Türk Kardiyol Dern Arú Vol 34, Suppl 1 , Oct, 2006, SB-140, s.68. XXII. Ulusal Kardioloji Kongresi, 24-28 KasÕm, 2006, Antalya 7. T.Alkan, A.Akçevin, T. Paker, H. Türko÷lu, C. Ersoy, V. Bayer, Ü. Duman, A. Aytaç. Koroner Bypass Cerrahisinde KullanÕlan Radial Arter Greft kullanÕlan olgularÕn anjiyografik yönden açÕk kalÕm oranlarÕ de÷erlendirilmesi ve SonuçlarÕmÕz:(sözlü sunum). Türk Kardiyol Dern Arú Vol 34, Suppl 1 , Oct, 2006, SB-154, s.72. XXII. Ulusal Kardioloji Kongresi, 2428 KasÕm, 2006, Antalya 8. Paker T, Türko÷lu H, Akçevin A, Bayer V, Alkan T, Öklü L, Aytaç A. Tüm subvalvüler yapÕlarÕn korunarak mitral kap replasmanÕ yapÕlmasÕnÕn sonuçlarÕ: Sol ventrikül volümü ve fonksiyonlarÕ üzerine etkiler. (sözlü sunum). Türk Kardiyol Dern Arú Vol 34, Suppl 1 , Oct, 2006, SB-62, s.18. XXII. Ulusal Kardioloji Kongresi, 24-28 KasÕm, 2006, Antalya